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November 6, 2017 - Methylation, SNP’S and SOLUTIONS by Marc Harris ND, MD, PhD

Methylation, SNP’S and SOLUTIONS by Marc Harris ND, MD, PhD

November 6, 2017 Puzzle Piece

SNP’s (pronounced “snips”) are the most common type of genetic variation among people. Each SNP represents a difference in a single DNA building block, called a nucleotide. Testing for and treating SNP’s with a natural approach, is not as complicated as it used to be with new innovations developed by Dr Marc Harris.
For a simplified testing and treating method, join us at Brimhall Homecoming February 23-25, 2018 in Tempe, AZ.  We will review the many aspects of methylation, testing and treating, including the recently developed muscle testing sequence.  The necessary kit for testing will be available for you to acquire at the seminar

Dr Harris will do a Webinar with me on December 6, 2017 at 7pm MST to assist your understanding. 

We will send a link for your free registry in a few days.
A short history from Dr Harris:

1985 - Gregor Mendel (Mendelian genetics) hybridizes a green pea with a yellow pea and produced a green pea.  Generations of kids are now happy as they like peas:  Usually the green foods many people eat.
1869 – Freidrich Mieschner discovers “nuclein” in white blood cells made up of hydrogen oxygen phosphorus and nitrogen.  Nuclein was    actually DNA
1952 Rosalind Franklin show x-r diffraction od DNA
She later dies of radiation poisoning.
1953 Francis Watson and James Crick discover
the double helix.
1961 Marshal Nirenberg discerns how DND codes for proteins.
1990 Human genome Project begins.
2003 Human Genome project completed.  We only have 20,000 genes
1965 The discover of DNA methylation

Methylation:  As we are developing embryonically, we are differentiated into the body systems and cells of a human being.  Once we form 2 elbows we don’t need any more:  2 lungs, kidneys 1 liver etc.  To stop genetic production of DNA we use methylation.  If methylation is off via a SNP (Single Nucleotide Polymorphism) it can change the gene function from 30-70%.  Some homozygous SNP’s are not compatible with life.
DNA is methylated at different locations. For example:  HMT methylates at the level of histone proteins.  DMNT1 (DNA Methyl transferase) show to contain SNPS directly related to diseases.  CPG island hypermethylation is shown in cancer cells.
Genetic SNP’s are also dependent of various minerals.  If needed minerals are not consumed there is decreased function even in a non-SNP containing gene.  This deficiency is often termed genetic nutritioneering.  In a gene with a SNP, people can be given higher amounts of these nutrients to increase genetic function.
Folic acid is not folate. It is a synthetic form that slowly converts to tetrhydrofolate.  If there is a SNP (MTHFR) then folic acid actually blocks folate metabolism.  Folate is an essential vitamin.  Folic acid is ineffective at best, dangerous at the worst.  Folate is termed from the latin folium (meaning leaf).  Folate is dense in dark leafy greens; (iceburg lettuce is not a dark leafy green).

Testing for MTHFR is useful and incomplete.  If you have a downstream SNP and you supplement Folate, you will further drive the downstreanm SNP and people will get worse.  The methylation SNP’s are a bit like this image.

 One change and they all come tumbling down.  The entirety of the pathways must be considered.  This is not as difficult as it sounds if you have an understanding of the entire flow.  The most common testing methods are:
  1. Bisulfite genomic sequencing
  2. Methylation-sensitive restriction endonucleases
  3. Methylated DNA immunoprecipitation
Is it good to test?  Yes,  Methylation SNP’s cause problems with detoxification, emotional balance, successful pregnancies and childbirths, energy, control of DNA, cancer, inflammation, diabetes, fibromyalgia/Chronic Fatigue Syndrome, pulmonary embolism, addictive behavior, even alcoholism, insomnia, autism or down’s syndrome, bipolar or manic depression, allergies or multiple chemical sensitivities, atherosclerosis, spina bifida, cleft palate, neural tube defects multiple sclerosis and other autoimmune disorders, Hashimoto’s, hypothyroidism, ADD or ADHD, Dementia/Alzheimer’s, schizophrenia, snxiety, seuropathy, Lyme Disease, chronic infections, candida, parasites and SIBO to name a few.
These pathways are depleted by most drugs, alcohol and a poor diet.  It would be helpful to test every patient because of the many possible SNP’s and combinations.
Join us for the December 6, 2017 webinar and Homecoming 2018 on February 23-25 in Tempe, Arizona for “The Rest of the Story.”

To register for the 2018 Homecoming Click Here

To Download the 2018 Homecoming Itinerary Click Here

Yours in Health and Wellness,

Marc Harris, ND, MD, PhD, PhD, PhD
John W Brimhall, DC, BA, BS, FIAMA, DIBAK

Marc Harris, ND, MD, PhD, PhD, PhD
John W Brimhall, DC, BA, BS, FIAMA, DIBAK

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