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October 6, 2014 Puzzle Piece The Triad of Gut Destruction and Immunogenicity of Foods

October 6, 2014 Puzzle Piece  


Homecoming Updates +

The Triad of Gut Destruction and Immunogenicity of Foods

by Cheryl Burdette, ND


The gut is the major interface to the outside world. It is our first line of defense as well as where our first exposure happens. It is where we decide if we are immune tolerant of the world or inflamed by the world. Recent research by Dr. Fasano demonstrates that the inflammatory contribution from the gut results in a host of systemic conditions, from neurologic to auto-immune but even contributing to diabetes and some cancers. He also affirms that movement away from a disease centered paradigm is possible by recognizing underlying processes that are occurring before pathology is evident. We will review highly evidenced biomarkers that map care. The gut is our window to prevention and remission. By addressing the triggers of histamine, pathogens and food sensitivities, as well as the body's ability to handle the assault, through enzymes such as diamine oxidase that degrade histamine, we can halt inflammation and truly practice healthcare and promote wellness.1-29

Objectives discussed for Homecoming Presentation:

1)    To understand the extensive influence the gut has on a myriad of pathologies not limited to the GI system. We will review the systemic inflammatory pathways that are triggered from gut health.

2)    To understand and be able to actualize the use of cutting-edge biomarkers such as Zonulin, Diamine oxidase, stool culture assessment and C3d/IgG food sensitivity assessment as they result to inflammatory process and pathology.

3)    Review the research and evaluate the strength of the literature as it applies to biomarkers and successful natural modulation of these markers.

4)    Review medications used in gastroenterology and their effects on diamine oxidase as well as Zonulin and LPS. We will cover PPIs, antibiotics as well as antidepressants and their gut effects.

3. Relevance to the medical profession.

This case based presentation will focus on biomarkers that enhance clinical direction and help in selecting appropriate treatments. Understanding biomarkers can't help to direct length of treatment as well as dosing of therapies.

4. Brief Speaker Bio

Dr. Cheryl Burdette, ND is chief scientific advisor of Dunwoody Labs. She is the Educational director, clinician and runs a residency program for NDs at Progressive Medical, one of the largest integrative clinics in the country. She serves on IRBs, and is an author in the book, "Laboratory Evaluations of Molecular Medicine." Dr. Burdette lectures extensively nationally and internationally. She graduated from Bastry University in 2001, and she completed her residency at Cancer Treatment Centers of America. Her marriage between laboratory director and clinical practice give her a unique perspective in functional medicine treatment and testing.

Brief Outline of Course

I.    Breast Milk And Leaky Gut

A.  Constituents of Breast Milk

B.    Application of breast milk compounds to clinical practice

C.    Diamine Oxidase and its protective effects on the gut

D.  Diamine Oxidase and its importance on other systemic pathology such as headaches, arrhythmia, depression

II.         Zonulin and Leaky Gut

A.  Pathophysiology of Zonulin

B.    Conditions Associated with Zonulin

C.    Treatments for Zonulin

III.      LPS

A.  Bacterial Endotoxin and its Meaning

B.    Cardiovascular Disease and LPS

C.    Athletes and LPS

IV.   Leaky Gut and Immunogenicity of Foods

A.    Factors that Increase Immunogenicity of Foods

B.    Measurements of IgG and What They Tell Us

C.    Measurements of Complement and What it Tells Us

D.    Treatments For Improving Gut Health and Permeability


1.     Maintz L, Novak N. Histamine and histamine intolerance. Am J Clin Nutr. May 2007;85(5):1185-1196.

2.     Maintz L, Schwarzer V, Bieber T, van der Ven K, Novak N. Effects of histamine and diamine oxidase activities on pregnancy: a critical review. Human reproduction update. Sep-Oct 2008;14(5):485-495.

3.   Hamada Y, Shinohara Y, Yano M, et al. Effect of the menstrual cycle on serum diamine oxidase levels in healthy women. Clin Biochem. Jan 2013;46(1-2):99-102.

4.    Bjelakovic L, Kocic G, Bjelakovic B, et al. Polyamine Oxidase and Diamine Oxidase Activities in Human Milk during the First Month of Lactation. Iranian journal of pediatrics. Jun 2012;22(2):218-222.

5.     Karabulut KU, Narci H, Gul M, et al. Diamine oxidase in diagnosis of acute mesenteric ischemia. The American journal of emergency medicine. Feb 2013;31(2):309-312.

6.     Maintz L, Benfadal S, Allam JP, Hagemann T, Fimmers R, Novak N. Evidence for a reduced histamine degradation capacity in a subgroup of patients with atopic eczema. The Journal of allergy and clinical immunology. May 2006;117(5):1106-1112.

7.   Fasano A. Intestinal permeability and its regulation by zonulin: diagnostic and therapeutic implications. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association. Oct 2012;10(10):1096-1100.

8.   ; Fasano A. Zonulin, regulation of tight junctions, and autoimmune diseases. Ann N Y Acad Sci. Jul 2012;1258:25-33.

9.   Fasano A. Leaky gut and autoimmune diseases. Clinical reviews in allergy & immunology. Feb 2012;42(1):71-78.

10.    Fasano A. Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer. Physiological reviews. Jan 2011;91(1):151-175.

11.   Schmidt WU, Sattler J, Hesterberg R, et al. Human intestinal diamine oxidase (DAO) activity in Crohn's disease: a new marker for disease assessment? Agents and actions. Apr 1990;30(1-2):267-270.

12.    Wollin A, Wang X, Tso P. Nutrients regulate diamine oxidase release from intestinal mucosa. Am J Physiol. Oct 1998;275(4 Pt 2):R969-975.

13.   Liu Y, Chen F, Odle J, et al. Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge. J Nutr. Nov 2012;142(11):2017-2024.

14.   Buts JP, De Keyser N, Marandi S, et al. Saccharomyces boulardii upgrades cellular adaptation after proximal enterectomy in rats. Gut. Jul 1999;45(1):89-96.

15.    Namikawa T, Fukudome I, Kitagawa H, Okabayashi T, Kobayashi M, Hanazaki K. Plasma diamine oxidase activity is a useful biomarker for evaluating gastrointestinal tract toxicities during chemotherapy with oral fluorouracil anti-cancer drugs in patients with gastric cancer. Oncology. 2012;82(3):147-152.

16.    Wantke F, Gotz M, Jarisch R. Histamine-free diet: treatment of choice for histamine-induced food intolerance and supporting treatment for chronic headaches. Clin Exp Allergy. Dec 1993;23(12):982-985.

17.   Karsten CM, Kohl J. The immunoglobulin, IgG Fc receptor and complement triangle in autoimmune diseases. Immunobiology. Nov 2012;217(11):1067-1079.

18.    Ebbo M, Grados A, Bernit E, et al. Pathologies Associated with Serum IgG4 Elevation. International journal of rheumatology. 2012;2012:602809.

19.   Schiffer C, Lalanne AI, Cassard L, et al. A strain of Lactobacillus casei inhibits the effector phase of immune inflammation. Journal of immunology. Sep 1 2011;187(5):2646-2655.

20.   Liu ZH, Huang MJ, Zhang XW, et al. The effects of perioperative probiotic treatment on serum zonulin concentration and subsequent postoperative infectious complications after colorectal cancer surgery: a double-center and double-blind randomized clinical trial. Am J Clin Nutr. Jan 2013;97(1):117-126.

21.    Murzyn A, Krasowska A, Augustyniak D, Majkowska-Skrobek G, Lukaszewicz M, Dziadkowiec D. The effect of Saccharomyces boulardii on Candida albicans-infected human intestinal cell lines Caco-2 and Intestin 407. FEMS Microbiol Lett. Sep 1 2010;310(1):17-23.

22.   Fasano A. Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall. The American journal of pathology. Nov 2008;173(5):1243-1252.

23.   Wang W, Uzzau S, Goldblum SE, Fasano A. Human zonulin, a potential modulator of intestinal tight junctions. Journal of cell science. Dec 2000;113 Pt 24:4435-4440.

24.     Brand S. Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease. Gut. Aug 2009;58(8):1152-1167.

25.    Vighi G, Marcucci F, Sensi L, Di Cara G, Frati F. Allergy and the gastrointestinal system. Clinical and experimental immunology. Sep 2008;153 Suppl 1:3-6.

26.   Lamprecht M, Bogner S, Schippinger G, et al. Probiotic supplementation affects markers of intestinal barrier, oxidation, and inflammation in trained men; a randomized, double-blinded, placebo-controlled trial. Journal of the International Society of Sports Nutrition. 2012;9(1):45.

27.    Kronfol Z, House JD. Lymphocyte mitogenesis, immunoglobulin and complement levels in depressed patients and normal controls. Acta psychiatrica Scandinavica. Aug 1989;80(2):142-147.

28.    Nakamura K, Sato T, Ohashi A, Tsurui H, Hasegawa H. Role of a serotonin precursor in development of gut microvilli. The American journal of pathology. Feb 2008;172(2):333-344.

29.    Bubenik GA. Thirty four years since the discovery of gastrointestinal melatonin. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. Aug 2008;59 Suppl 2:33-51.


HOMECOMING JANUARY 23-25, 2015 in Tempe, Arizona

John W Brimhall, DC, FIAMA, DIBAK:  The Six Steps to Wellness, with new  insights, including advanced laser(s), the Female Brain, Male Brain, Methylation, Detoxification and Cellular Regeneration through REDOX SIGNALING MOLECULES, Mitochondrial Resuscitation, Inflammation & Autoimmune Conditions .

Brett B. Brimhall, DC:  Integrating Practice Procedures to allow easy flow for Wellness Care, including weight loss and body contouring, brain balance, neurology, laser(s) in action, detox, foot baths, sauna, Craniosacral, PEMF, Power Plate... + Workshops on ALL SIX STEPS

Cheryl Burdette, ND: The Triad of Gut Destruction and Immunogenicity of Foods, inflammation, symptomatic expressions & auto-immunity... with complexity recognition, evaluation and treatment.

Ryan Frace, MS: The 12 most common nutrient considerations in practice, with the latest research and new innovative nutrition to back it up. Insights on products that are ONLY sold to Professionals!

Jessie Liebman, DC on adjuncts to the Chiropractic Adjustment and the Six Steps to Wellness, with emphasis on Body Contouring, Detoxification and helping achieve the Ideal Weight and Shape.  Yes he did way over a million in services rendered and collected last year and new records in progress.

Van Merkel, DC, DABCI, DCBCN, CNN:  back by popular demand on Blood, Hair and Toxic Urine challenges to asses and treat the patient with exactness, based on the Scientific Literature and a computerized reporting system.  He makes patient evaluation and documentation understandable and reproducible for YOU. + Workshop

John Krage, DC: Did over a Million last year creating patient body balance and function, using the evaluation of the lower extremities, including feet and an extremely complete orthotic system.  He will show you evaluation, presentation and treatment including advanced laser protocols.  + Workshop

Scott Kramer, DC on how to create the Practice of Your Dreams.  He will show you the way to visualize and materialize the practice, you too can accomplish using the Six Steps to Wellness.  He practices and coaches to GREAT SUCCESS.  Yes he too did over a Million Dollars last year and so do many of his clients.

Garry Gordon, DO, MD, MD (H) will present the latest research in  Oxidative Medicine. The Free Radical  Theory of AGING is now recognized  to be wrong.  Certain Free Radicals generated by our mitochondria  such as REDOX SIGNALING MOLECULES  are essential  for OPTIMAL  Health and Longevity.  Remarkable research  document enhanced Human Performance and a 500-800% increase in intracellular Glutathione.  Therefore, this approach will  significantly improve our ability to manage EVERY  health challenge.  (including skin cancer)

Dave Smaldone, DC is one of the leading Trainers and Chiropractors in evaluation and taping of the complicated patient.  He will teach evaluation, treatment and supportive taping. + Workshop

Brandy Brimhall, CPC, CMCO, CCCPC, CPCO on documentation, coding and compliance. It is a must for what you need and must know to keep current, protect you, your patient and your license.  + Workshop
Yours in Health and Wellness,
John W. Brimhall, BA, BS, DC, FIAMA, DIBAK

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